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star, score, rank, reviewHighly Rated
Nike Run Defy Women's Road Running Shoes - Black/Wolf Grey/White

Nike Run Defy

Women's Road Running Shoes

$65
star, score, rank, reviewHighly Rated
  • Nike Run Defy Women's Road Running Shoes - Black/Wolf Grey/White
Black/Hyper Pink/Pink Foam/Elemental Pink
Black/Wolf Grey/White
White/Black/Pure Platinum
White/Football Grey/Work Blue/Blue Void
Summit White/White/Malachite/Metallic Silver
Sail/Summit White/Chalk/White
Particle Rose/Sail/Tattoo/Hydrogen Blue
Select Sizeruler, dimension, size, lengthSize Guide

Shipping

You'll see our shipping options at checkout.
Free Pickup
  • Shown: Black/Wolf Grey/White
  • Style: HM9593-002

Nike Run Defy

$65

Run by your own rules in the all-new Nike Run Defy. A foam midsole, breathable upper and reliable traction combine to make a shoe that’s raring for runs of all lengths and paces.

Key Features

  • Mesh on upper adds breathability.
  • Foam midsole delivers a soft ride.
  • Flex grooves create a cushioned effect for your run.
  • Waffle outsole is made of a durable, flexible material that helps keep you on the move.
  • Increased rubber at the outsole provides traction and durability.

Product Details

  • Weight: Approx. 233 g/8.2 oz (Women’s US 8)
  • Heel-to-toe drop: 10 mm
  • Shown: Black/Wolf Grey/White
  • Style: HM9593-002

Shipping & Returns

Free standard shipping on orders $50+ and free 60-day returns for Nike Members. Learn more. Return policy exclusions apply.

Pick-up available at select Nike Stores.

Reviews (213)

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star, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, review

4.7 Stars

  • So comfy

    star, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, review

    Stephanie585313318 - Jun 03, 2026

    I work a 19 hour day on my feet almost the whole time . These shoes are comfortable the whole day ,supportive and look great. They are also great quality most shoes last me a couple months ,im super hard on shoes .these shoes have already lasted me 9 months and still have life in them. I dont use these shoes for running

  • Comfortable shoes, Great for walking!

    star, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, review

    dellad829812244 - Jun 01, 2026

    I absolutely love these Nikes. They are so comfortable. I walk a lot at work and they are awesome.

  • star, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, reviewstar, score, rank, review

    MelissaH682785964 - May 30, 2026

    Very comfortable shoes. I like the fit and style.

See Reviews
Nike Run Defy Women's Road Running Shoes

Nike Run Defy

$65

Breathable upper, reliable traction and foam midsole deliver all day comfort.

Engineered For

Road Running

Cushion

All Day Comfort

Shoe Weight

Approx. 233g/8.2oz (Women’s US 8)

Heel-to-Toe Drop

10mm

Tech Specs

Shoe Weight

Approx. 233g/8.2oz (Women’s US 8)

Heel-to-Toe Drop

10mm

Features That Perform

  • Mesh Upper

    Mesh on the upper adds breathability.

  • Foam Midsole

    Foam midsole delivers a soft ride.

  • Waffle Outsole

    Waffle outsole is a made of a durable, flexible material that helps keep you on the move.

Complete the Look

  • Nike Zenvy Women's High-Waisted Full-Length Leggings with No Front Seam
    Nike Run Defy Women's Road Running Shoes
    Nike Universa Women's Medium-Support Padded Sports Bra
    Nike Everyday Elevated Crew Socks (3 Pairs)
    Nike Apex Dri-FIT Bucket Hat
    Nike ACG "Solar Chase" Women's Dri-FIT Trail Running Tank Top
  • Nike Tempo Women's Dri-FIT Mid-Rise Brief-Lined Running Shorts
    Nike Refuel Water Bottle (24 oz)
    Nike Swift Women's Dri-FIT Running Tank Top
    Nike Swoosh Women's Medium-Support Padded Sports Bra
    Nike Run Defy Women's Road Running Shoes
  • Nike ACG "Lava Loft" Women's Therma-FIT Trail Running Jacket
    Nike Universa Women's Medium-Support Padded Sport Bra
    Nike Therma-FIT High-Pile Fleece Gloves
    Nike Swift Women's Dri-FIT Mid-Rise Running Pants
    Nike Women's Dri-FIT Graphic T-Shirt
    Nike Run Defy Women's Road Running Shoes
  • Nike AeroSwift Women's Dri-FIT ADV Mid-Rise 3" Brief-Lined Running Shorts
    Nike Run Defy Women's Road Running Shoes
    Nike ACG Everyday Elevated Ankle Socks (1 Pair)
    Nike Swoosh Women's Medium-Support Padded Sports Bra
    Nike AeroSwift Women's Dri-FIT ADV Cropped Running Tank Top
    Nike Apex Dri-FIT Bucket Hat
  • Nike Swift Women's High-Waisted 4" Tight Running Shorts with Pockets
    Nike Pro Women's Loose T-Shirt
    Nike Swoosh Women's Medium-Support Padded Sports Bra
    Nike Run Defy Women's Road Running Shoes
    Nike Recharge Stainless Steel Chug Bottle (32 oz)
  • Nike ACG "Smith Summit" Women's UV-Resistant Jacket
    Nike One Women's Dri-FIT Skirt
    Nike Run Defy Women's Road Running Shoes
    Nike Alate Minimalist Women's Light-Support Padded Convertible Sports Bra
    Nike Sportswear Club Fleece Women's 1/2-Zip Sweatshirt
  • Nike Indy High Support Women's Padded Front-Zip Sports Bra
    Nike Run Defy Women's Road Running Shoes
    Everyone Watches Women's Sports™ Nike by TOGETHXR Cap
    Nike AeroSwift Women's Dri-FIT ADV Mid-Rise 3" Brief-Lined Running Shorts
    Nike Swift Women's Dri-FIT UV Long-Sleeve Crew-Neck Running Top
  • Nike One Women's High-Waisted 5" Biker Shorts
    Nike Run Defy Women's Road Running Shoes
    Nike Indy High Support Women's Padded Front-Zip Sports Bra
    Nike Swift Women's Dri-FIT UV Long-Sleeve Crew-Neck Running Top
    Nike Brasilia 9.5 Training Duffel Bag (Medium, 60L)
    Nike Club Unstructured Cap
  • Nike Swoosh Women's Medium-Support Padded Sports Bra
    Nike Swift Women's Dri-FIT Full-Zip Mid-Layer Running Top
    Nike Attack Women's Dri-FIT Fitness Mid-Rise 5" Unlined Shorts
    Nike Pro Women's Dri-FIT Short-Sleeve Top
    Nike Run Defy Women's Road Running Shoes
  • Nike Form Women's Light-Support Non-Padded Triangle Sports Bra
    Nike Academy Team Backpack (30L)
    Nike Club Lanyard
    Nike Pro Sculpt Women's High-Waisted 7/8 Leggings with Pockets
    Nike Dri-FIT Women's T-Shirt
    Nike Run Defy Women's Road Running Shoes
  • Nike Swift Women's High-Waisted 4" Tight Running Shorts with Pockets
    Nike One Fitted Women's Dri-FIT Cami Tank Top
    Nike Heritage Backpack 2.0 (23L)
    Nike One Women's Light-Support Padded Sports Bra
    Nike Run Defy Women's Road Running Shoes
  • Nike Therma-FIT One Women's High-Waisted 7/8 Joggers
    Nike USA Sport Scarf
    Nike Run Defy Women's Road Running Shoes
    Nike Sportswear Club Fleece Pullover Hoodie
    Nike ACG Dri-FIT Balaclava
  • Nike Running Lightweight No-Show Socks (1 Pair)
    Nike Alate Minimalist Women's Light-Support Padded Convertible Sports Bra
    Nike Run Defy Women's Road Running Shoes
    Nike Universa Women's High-Waisted 8" Biker Shorts with No Front Seam
    Nike After Dark Tour Women's Loose Short-Sleeve T-Shirt
  • Nike Pro Women's Therma-FIT Hoodie
    Nike One Wrap Women's High-Waisted 7/8 Leggings
    Nike Women's Dri-FIT Graphic T-Shirt
    Nike Run Defy Women's Road Running Shoes
    Nike Form Women's Light-Support Non-Padded Triangle Sports Bra
    Nike Dri-FIT Club Unstructured Metal Swoosh Cap
  • Nike Pro Women's Mid-Rise 3" Biker Shorts
    Nike Run Defy Women's Road Running Shoes
    Nike Storm-FIT ADV Club Structured AeroBill Cap
    Nike Everyday Essential Ankle Socks (3 Pairs)
    Nike Swoosh Women's Medium-Support Padded Sports Bra
    Nike One Relaxed Women's Dri-FIT Short-Sleeve Top
  • Nike 24.7 PerfectStretch Women's Dri-FIT High-Waisted Loose Barrel-Leg Pants
    Nike Run Defy Women's Road Running Shoes
    Nike One Twist Women's Light-Support Lightly Lined High-Neck Sports Bra
    Nike Air Max 90 Card Wallet
    Nike 24.7 ImpossiblySoft Women's Dri-FIT Oversized 1/2-Zip Top
  • Nike Running Lightweight No-Show Socks (1 Pair)
    Nike Attack Women's Dri-FIT Fitness Mid-Rise 5" Unlined Shorts
    Nike Apex Dri-FIT Bucket Hat
    Nike Run Defy Women's Road Running Shoes
    Nike Sportswear Chill Knit Women's Tight Cropped Mini-Rib Tank Top
    Nike Form Women's Light-Support Non-Padded Triangle Sports Bra
Item 3 of 17

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